Depression: Numerous studies have confirmed that oral microorganisms, particularly bacteria, play a vital role in overall health. Now, recent research suggests that depression may be linked to a reduced diversity of bacteria in the mouth. Researchers at NYU Rory Meyers College of Nursing have identified a connection between depression and lower bacterial variety in the oral microbiome. Depression, a complex mental health disorder marked by persistent sadness, hopelessness, and disinterest in daily activities, could be tied to imbalances in oral health.

“The mouth hosts a wide range of microbes, including bacteria, viruses, and fungi, all of which contribute to both oral and systemic health,” the researchers explained. They found that individuals with depression tend to have less microbial diversity in their mouths compared to those without the disorder.

Bei Wu, the study’s senior author and vice dean for research at NYU Rory Meyers, emphasized the potential impact of these findings. “A deeper understanding of the relationship between the oral microbiome and depression could not only reveal the biological mechanisms behind mood disorders but also lead to the development of new biomarkers or treatments,” Wu said in an official statement.

This growing body of evidence highlights a surprising link between oral hygiene and mental health, suggesting that brushing your teeth may influence more than just your smile.

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BMC Oral Health Report:

The journal BMC Oral Health recently published findings from a study conducted by the Centers for Disease Control and Prevention (CDC). Researchers used data from over 15,000 U.S. adults aged 18 and older, gathered through the National Health and Nutrition Examination Survey (NHANES), to investigate the connection between oral bacteria and depression.

From 2009 to 2012, the CDC collected saliva samples and analyzed participants’ responses to depression symptom questionnaires. The team discovered that individuals with lower oral microbiome diversity showed a higher tendency to experience depressive symptoms. Researchers noted that factors like dental hygiene, alcohol consumption, and smoking significantly influence the composition of oral bacteria.

The study team suggested that the oral microbiota might affect depression symptoms by triggering inflammation or influencing the immune system. At the same time, depression itself can disrupt oral microbiota through behaviors such as poor dental care, increased tobacco and alcohol use, dietary changes, or medication use.

Bei Wu, the study’s senior author and vice dean for research at NYU Rory Meyers College of Nursing, emphasized the need for further research. “We need to better understand the direction and mechanisms of this association,” Wu said. “This work is part of our broader investigation into how the oral microbiome impacts not only mental health but also cognitive decline and the development of dementia.”

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